TAY-SACHS DISEASE & SANDHOFF'S DISEASE

Tay-Sachs disease is a genetic disease in which the enzyme hexosamindase-A is deficient; Sandhoff’s disease occurs when hexosamindase A and B are low or absent and results in major neurological damage to the child. Although originally thought to occur only in families of Jewish heritage the defective gene has now been found in diverse populations in the Middle East, Ireland, Italy, Phillipines, Eastern Europe.

Until recent times there has been no treatment available for either of these conditions.

The infantile form of Tay-Sachs is noted by a normal developmental period the first six months after which the baby loses its neck control, ability to turn over front to back or reverse; unable to sit or crawl or stand. Later between 15-24 months of age the child develops a cherry red spot in the eyes, loses its ability to see and hear. A juvenile form of the disease also occurs in some cases in which the neurological degeneration oocurs after five years of age.

Sandhoff’s disease is very similar to Tay-Sachs except that both the hexo A and B enzymes are deficient.

STEMCELLREGENMED has developed a protocol which includes the following:

1. Administration of neuron brain/spinal cord stem cells into the central nervous system via the spinal canal thus replacing and repairing these tissues.
2. Enzyme replacement therapy to increase the levels of hexosaminidase enzyme.
3. Molecular chaperone therapy to correct the misfolded mutant enzyme hexosamindase that will increase its level and functionality using agents such as Celastrol, NGT or NN-DNJ
4. Substrate deprivation to reduce or eliminate the excessive fatty accumulations in the lysosomes that then damage the brain and spinal cord.
5. Specific patient candidates chosen for gene therapy with cDNA (alpha polypeptide) Hexosaminidase A and B.
   

Medical Disclaimer: Treatments discussed on this website are experimental and have not been approved by the FDA. No guarantees are made regarding the results of these treatments. Prospective patients are advised to discuss the use of a Stem Cell treatment for their disease with their physician.

TAY-SACHS DISEASE VIDEO

Click to view video from Dr. Feinerman